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At 88 days of age vehicle, 25 nmol/kg and 75 nmol/kg dosed animals weighted 17.1 0.9 g, 17.8 1.1 g and 17.6 1.2 g respectively (overall P = 0.3165, two-way ANOVA with repeated measures)
But the absolute amount of lean mass lost is still significant because the total weight loss is so large
That is a meaningful window for identifying common and uncommon adverse events, but it does not address what happens at year two, year three, or beyond
This reduction in cravings can contribute to better adherence to a healthier diet, promoting weight loss
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