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Further, small changes in lipid parameters and DBP were noted over 12 months, with moderate improvements in SBP

Potential direct anti-inflammatory mechanisms from preclinical and early clinical studies include: Modulation of immune cell function : GLP-1 receptor activation may reduce pro-inflammatory cytokine production from macrophages and other immune cells Reduction of oxidative stress : These medications may decrease reactive oxygen species production, which contributes to inflammatory processes Endothelial protection : GLP-1 receptor agonists may improve endothelial function and reduce vascular inflammation Inhibition of inflammatory signalling pathways : Including suppression of nuclear factor-kappa B (NF-B), a key regulator of inflammatory gene expression It's important to note that many of these mechanisms have been primarily demonstrated in laboratory or animal studies, with more limited evidence in humans

doi: 10.1016/0198-8859(86)90079-0 119 de VriesRRPSchreuderGNaipalADAmaroJvan RoodJJ

Ozempic is prescribed to people with type 2 diabetes, typically after the drug metformin has been tried, and it may well increase the risk of a rare form of blindness (to be confirmed)