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The development of GLP-1RAs The Gila monster, which lives in the deserts of the Americas, can eat up to half its own body weight in one sitting, but its blood sugar remains stable, and its metabolic system runs smoothly despite this large amount of food

Therefore, it is possible that overexpression of PGC-1 not only induced a faster metabolization of the drug, with a concomitant accumulation of highly reactive intermediates, but also contributed to a rapid GSH depletion by Glutathione S-transferases

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