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Standardization of outcome measures and reporting: Outcome measures and reporting methods should be standardized across studies to facilitate better comparison and interpretation of the results
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The GLP-1 component activates hepatic AMPK/SIRT1 pathways, which inhibit SREBP-1c, a master regulator of de novo lipogenesis, thereby reducing hepatic triglyceride synthesis ( -oxidation of fatty acids and ketogenesis
Even among those taking high doses (over 1,000 mg per day), thyroid-stimulating hormone levels remained within normal ranges
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