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These pathogens disrupt oxidative phosphorylation, elevate mitochondrial ROS, and alter mitochondrial dynamics, leading to depolarized membrane potential and mtDNA release (Maekawa et al., 2019)
[15] [16] Note that febuxostat carries additional cautions for people with established cardiovascular disease
Furthermore, SGLT2i outperforms metformin in lowering body weight and FPG levels
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