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Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

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Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione

It remains unproven whether the differing molecular signatures are due to the route (bypassing the blood-brain barrier vs