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If no application was made, provide a specific reason (e.g., not eligible, awaiting documents, drug not listed) and include any relevant decision details if declined

All peptides were synthesized and purified using our standard solid-phase methods with aza-amino acid building blocks, and their identities and purities were confirmed by mass spectrometry ( Supplementary Table 1 ) 13

Patients ready for dose escalation typically demonstrate good medication adherence and have implemented recommended lifestyle modifications including dietary changes and increased physical activity

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