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Schon, F
The pentose phosphate shunt has two phases, the oxidative phase (reactions 21 - 23), in which NADPH and pentose-5-phosphate are generated, and the non-oxidative phase (reactions 24 - 28), in which unused pentose-5-phosphate can be converted to other sugar intermediates and then returned to the glycolytic pathway as glyceraldehyde-3-phosphate and fructose-6-phosphate
Some of these methods have already been shown to increase the delivery of intact peptides and other substances such as chemotherapy agents, biological markers, cellular ligands and receptors, and other substances to their intended targets in the body, thereby increasing overall bioavailability and effectiveness
Peter also dives into the potential upside of GLP-1s beyond weight loss and what evidence would justify broader use, explains why transcranial magnetic stimulation is on his radar, and shares his framework for evaluating body fat percentage
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