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The upper arm works for self-injection when the posterior (back) surface is targeted, though some patients find this location slightly more challenging than abdomen or thigh sites

Unlike approved agents such as semaglutide or tirzepatide, retatrutide's broader receptor activity particularly its glucagon component may produce a more pronounced chronotropic effect

After depressing the plunger completely, hold the needle in place for 5-10 seconds before withdrawing

If weight loss specifically has stalled despite good adherence, our guides on why semaglutide is not working and four weeks on semaglutide with no weight loss address the most common reasons and solutions