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Collectively, our data unravel a key role for TBC1D9B in controlling lysosome function by serving as a negative regulator of ARL8 activity
Different studies have demonstrated that theres a clear connection between high homocysteine levels and cardiovascular diseases (and related mortality)
GO term enrichment was then assessed using the enrichGO function from the ClusterProfiler 30 R package, with the parameter universe set to include all genes detected in the bulk RNA-seq data, minGSSize set to 10, maxGSSize set to 500 and pAdjustMethod set to BH
NAD+ and longevity stacks Given that 5-amino-1mq works by preserving NAD+ levels, combining it with direct NAD+ precursors like NMN or NR makes mechanistic sense
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