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In clinical gastroenterology, "leaky gut" is not a primary medical diagnosis like Crohn's disease or celiac disease.Increased intestinal permeability is a secondary consequence of underlying inflammation, dietary triggers, or microbiome dysbiosis

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Specifically, there is an increase in oxidative phosphorylation (OXPHOS), GSH synthesis, and reactive oxygen species (ROS) scavenging, which are closely linked to glutamine metabolism

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