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The main safety concern is in dogs with active cancer, as TB-500 promotes cell growth and blood vessel formation
The results are mixed: some musculoskeletal studies show enhanced local healing with proximal injection, while others show comparable efficacy between subcutaneous and peri-lesional routes
We propose that NADH-dependent glutamate dehydrogenase activity is favoured over NADPH production to meet the immediate energy requirements of the starved wild-type cells
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