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In patients with T2DM, adherence to GLP-1 RAs therapy is often suboptimal, although it tends to be higher among those receiving once-weekly formulations (57)
People with more visceral fat (apple shaped) tend to have higher cholesterol, blood sugar, and blood pressure at a given bodyweight than those whose fat is more evenly distributed around the body (hourglass or pear shaped)
Atogepant: first approval
Given existing evidence, triple combination therapy can be expected to provide additional cardiorenal protection, although further randomized controlled trials are needed to determine whether triple combination therapy actually has additive or synergetic effects compared with mono or dual therapy
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