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The GSTK1/RETREG1 complex conferred protection against diabetic tubular damage and kidney injury via modulating ER stress and apoptosis through the induction of reticulophagy, thereby revealing that maintaining ER homeostasis is crucial for the control of apoptosis (37)

Figure 4 The extracellular fragment of RAGE consists of three immunoglobulin-like parts: a variable N-terminal V-type domain, followed by two constant C1- and C2-type domains