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5-Amino-1MQ is a small-molecule competitive inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM)

Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

The right choice depends on whether the injury is discrete and localized or diffuse and multi-site