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It had also been discounted for the treatment of obesity because there was some prec-clinical evidence to suggest it was linked with weight gain
5 Conclusion In summary, GLP-1RAs have revolutionized obesity and diabetes management, offering potent weight loss and cardiometabolic benefits, but are best used in conjunction with lifestyle interventions, particularly exercise, to optimize health outcomes and sustainability
Inflammatory Cytokines and Sexual Desire CRP and IL-6, both elevated in obesity, directly suppress hypothalamic GnRH secretion and reduce androgen receptor sensitivity
Similar benefits have been observed in adults with obesity or overweight who also have cardiovascular disease
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