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Furthermore, membrane phospholipids bound to polyunsaturated fatty acids (PUFAs) are highly sensitive to free radical damage, leading to the accumulation of lipid peroxides (such as LOOH) [52]

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Evidence supports the role of dysbiosis in MS, particularly on immune regulatory pathways

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Ito K, Hanazawa T, Tomita K, Barnes PJ, Adcock IM: Oxidative stress reduces histone deacetylase-2 activity and enhances IL-8 gene expression: role of tyrosine nitration

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