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Learning objectives Describe Ehlers Danlos syndrome Recognize the symptoms and signs of Ehlers Danlos syndrome Anesthetic management of a patient with Ehlers Danlos syndrome Definition and mechanisms Ehlers Danlos syndrome (EDS) comprises a group of clinically and genetically heterogeneous heritable connective tissue disorders, characterized by joint hypermobility and instability, skin texture anomalies, and vascular and internal organ fragility Clinical manifestations range from extremely mild phenotypes to life-threatening complications depending on the specific subtype The current Villefranche nosology recognizes six major subtypes, comprising classic, hypermobile, vascular, kyphoscoliotic, arthrochalasia, and dermatosparaxis, most of which are linked to mutations in one of the genes encoding for fibrillar collagen proteins or enzymes involved in post-translational modification of these proteins AD, autosomal dominant
Semaglutide is an effective option for adults with a BMI of 30 or higher or a BMI of 27 or higher, accompanied by health conditions such as hypertension or diabetes
The original ipamorelin paper showed a GHRP-like receptor response using GHRP and GHRH antagonists, but it did not prove that ipamorelin has a unique receptor conformation, a unique signaling pathway, or a fully characterized biased-agonism profile
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