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9.6 Probiotics in obesity and cardiometabolic health Among the multiple factors driving the modern escalation of obesity, the most prominent are an inherited genetic susceptibility and a sustained energy imbalance, defined by a chronic excess of caloric intake relative to energy expenditure (412)
Together, they produce a GH elevation greater than either alone, with CJC-1295 human clinical trial data confirming mean GH concentrations increasing 2 to 10-fold and IGF-1 levels rising 1.5 to 3-fold following GHRH-analogue administration
doi: 10.3181/00379727-149-38889 51 QiG.MiY.ShiX.GuH.BrintonR
Key takeaways: 27% of respondents noticed changes to their menstrual cycle since starting GLP-1 medication for weight loss Respondents with PCOS were more likely to experience cycle changes, and 43% of this group reported noticing changes to their menstrual cycle The most commonly reported cycle changes were more predictable periods, more frequent periods, and shorter periods GLP-1 medications like semaglutide (Ozempic) and tirzepatide (Mounjaro) have traditionally been used to treat diabetes
