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doi:10.1016/S0149-2918(00)88479-9

Meta-analyses show mean diferences in HbA1c reductions versus placebo of 1.4% to 0.5% [20, 22, 2427]

9 , e016906 (2020)

The following is a review of the preclinical and clinical studies examining the role of GLP-1R agonists on the vascular endothelium and HFpEF: Data from preclinical studies In a study on non-diabetic mice models with arterial hypertension (simulating preconditions for HFpEF), Liraglutide treatment improved blood pressure and cardiac hypertrophy in angiotensin II-induced arterial hypertension independent of glucose/insulin modulation leading to the reversal of cardiac hypertrophy