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However, tirzepatide does cause a clinically significant interaction, so whilst on tirzepatide the FSRH recommend alternative (non-oral) methods of contraception, or to add barrier methods for 4 weeks after initiation and after every dose increase

A study showed that Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose balance and lowers risk of metabolic disease

In its late-stage clinical trial, "the ratio of fat-mass loss to lean-mass loss for patients treated with tirzepatide was generally consistent with that reported in lifestyle-based treatments for obesity," the spokesperson said

Journal of Nanobiotechnology 19(1):118