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doi:10.1016/j.jbiotec.2015.09.004 Wang D, Wang C, Wu H, Li Z, Ye Q (2016) Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase

The major detoxification pathway of 4HNE involves GSTs 16

Excessive NO production interacts with ROS to generate peroxynitrite (ONOO ), a highly reactive nitrogen species capable of nitrating proteins and inactivating mitochondrial enzymes (Takatani et al., 2018