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Michalikov D, ma M, Slana O (2020) New insights in the mechanisms of impaired redox signaling and its interplay with inflammation and immunity in multiple sclerosis

Key Takeaways Kojic acid inhibits melanin production by blocking tyrosine, an amino acid needed to make melanin

Our roGFP2 measurements confirm (i) that dynamic roGFP2 sensing (or the physiological glutathionylation/deglutathionylation of regular surface-exposed cysteinyl residues) requires a glutaredoxin activity, and (ii) that glutathionylated proteins or metabolites should be very transient redox species when GSH and glutaredoxins are present (unless they are stabilized by a kinetic uncoupling mechanism) 5,32,34,35,61,62,63,64