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Mean change in body weight from baseline to Week 52 was a secondary endpoint.* Comparable weight reduction with RYBELSUS 14 mg vs Jardiance PIONEER 2 study design 1,3 In an open-label trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 822 adult patients with type 2 diabetes on metformin were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily

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Supplied as a stable lyophilized powder, it provides a consistent reagent for in-vitro and approved in-vivo studies in animals

Almost overnight, what had been an academic curiosity became a hotbed of industry innovation