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We note that MR-Egger regression has lower statistical power compared to other methods (e.g., IVW) due to its reliance on the Instrument Strength Independent of Direct Effect (InSIDE) assumption and its sensitivity to weak instruments
Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function
If weight loss plateaus despite compliance and proper dosing, then adding a second agent becomes reasonable
However, for some individuals, it may take longer, depending on factors such as their skin type, lifestyle, and the dosage administered
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