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The molecular structure of GLP-1 peptides is large, hydrophilic, and electrically charged, which severely limits the ability of the molecule to pass the outer layer of the skin and enter the bloodstream, says Edwin Davila, DO, resident physician and obesity medicine expert for the National Academy of Sports Medicine
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A microdose approach can be particularly effective for patients who are highly sensitive to GLP-1 medications or who prioritize facial aesthetics alongside weight loss
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