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Transdermally delivered estradiol achieves estrone-to-estradiol ratios closer to premenopausal physiology than oral estrogen because the liver is not the first site of exposure, thereby preserving the endocrine milieu necessary for optimal receptor signaling
doi: 10.3389/fphar.2025.1438318 Received 31 May 2024 Accepted 11 April 2025 Published 15 May 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by C
Michael Weintraub, assistant clinical professor of endocrinology at NYU Langone in New York
This difference in research maturity may influence how clinicians approach prescribing discussions and what they can reference when establishing protocols
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