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Costanza Alciati, Pharma Analyst, GlobalData, commented, Weight regain and reversal of cardiometabolic improvements are a huge limitation for all marketed GLP-1R agonists, not only for Zepbound. Results from the STEP 1 trial extension study investigating changes in body weight and cardiometabolic risk factors upon semaglutide treatment withdrawal show that upon treatment withdrawal at week 68, patients regained 11.6 per cent of body weight by week 120

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Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation