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The same investigators ran an after-the-fact post-hoc analysis in JAMA Cardiology 2026
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Published preservative efficacy studies describe a concentration-dependent curve: at 0.9%, bacteriostatic activity suppresses common skin-flora organisms through the documented 28-day multi-dose window
Two estimands (treatment regimen estimand and efficacy estimand), based on the ICH E9(R1) guidance 32 , were used to assess treatment efficacy from different perspectives and accounted for intercurrent events differently
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