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Compared with placebo, the extract group ate less: daily energy intake was about 748 kJ lower at week 12 and 545 kJ lower at week 24, and reductions in hunger and cravings reached significance at multiple points across the study [4]
This 28-day window is why vial size and reconstitution volume need to be planned together
One practical strategy is limiting fat intake to no more than 1015 grams per meal during the first 48 weeks of treatment
The SURMOUNT-4 trial specifically studied what happens when tirzepatide is stopped after 36 weeks of treatment
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