The secretion and release of numerous pro-inflammatory substances can result in vascular endothelial dysfunction, thereby further enhancing pulmonary microvascular permeability, which ultimately facilitates the occurrence and progression of ARDS (152, 153)
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GLP-1 protects the cardiac microvessels against oxidative stress, apoptosis, and the resultant microvascular barrier dysfunction in diabetes, contributing to improvement of cardiac function and cardiac glucose metabolism
Among 173 RA patients with overweight or obesity who were prescribed GLP-1 agonists and actually took them, 32% showed improvement in RA disease activity after 1 year, compared with 17% of 42 patients who were also prescribed the drugs but never started them, according to Veena Ranganath, MD, MS, of the University of California Los Angeles (UCLA), and colleagues