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A major output of the NRF2 transcriptional program is involved in redox regulation in which sulfur atoms play a central role, such as glutathione synthesis and reduction, thioredoxin synthesis and reduction, and cystine uptake (Yamamoto et al
e.g., under nutrient starvation, being able to provide substrates for ATP production and macromolecule synthesis (Zhang, 2013)
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In contrast to its effect on obesity, tirzepatide has shown remarkable results in neuroprotective qualities
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