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This perspective has shifted substantially over the past 2 decades as accumulating evidence has demonstrated that both tissues secrete bioactive peptides that function as hormones, influencing glucose metabolism, energy expenditure, reproductive physiology, and aspects of aging

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Supplementary Table 5 TRUUST analysis of differentially expressed genes after 24 hours of BDG exposure in human monocytes

It has also been found that when leptin is produced in the gastric epithelium, it acts locally to induce satiation signals