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Lastly, diabetic patients have a high prorenin levels that could contribute more significantly than renin to the pathogenesis of end-organ damage by stimulating PRR intracellular signaling ( Also at kidney level, RAS compartmentalization and independent regulation have been shown to play an important role in the pathogenesis of hypertension and diabetic nephropathy ( + balance at normal renal perfusion pressures together with promoting glomerular, tubular and interstitial inflammation and fibrosis

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Its in my lower back on my right side, no pain, just very sensitive to the touch and it travels around." - u/ChefCabrini "The Wegovy makes my skin on my right foot super sensitive, restless leg syndrome and sleeplessness." - u/Plus_Honeydew_2592 Others describe itchiness or altered taste : "My skin is very itchy