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Continued use is often necessary to maintain weight loss, as discontinuation of the medication can lead to weight regain

A 2018 review indicated that while most PPIs seem equally effective when taken correctly before meals, patients' adherence to instructions can vary greatly impacting their effectiveness

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For example, a Department of Veterans Affairs report on the effectiveness of health coaching found that self-identified health coaching interventions have the potential to produce small positive, statistically significant effects on decreasing HbA1c levels, reducing body mass index, increasing physical activity and reducing dietary fat