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We excluded patients with bariatric surgery history and required weight measurements during baseline (90 days pre-treatment), the first year post-treatment (year 1), and the second year post-treatment (year 2), yielding 34,143 semaglutide-treated and 16,034 tirzepatide-treated patients ( Figure S1 )

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Phase Split option Daily dose 50 mg morning + 50 mg midday Notes Some sources prefer split AM dosing because the plasma half-life is short (about 4 to 7 hours in rodent PK)

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The research versus pharmaceutical peptide comparison provides context on quality and safety standards across different peptide sources

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For patients exploring metabolic peptide options more broadly, reading about Retatrutide benefits can clarify where this treatment fits into your overall health strategy

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