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We chose this partial depletion model because hypo-dopaminergic activity, rather than complete lack of dopamine, is implicated with the patho-physiology of ADHD
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HPA axis dysfunction can be caused by various factors , including: Chronic stress: Prolonged exposure to stress, as well as an accumulation of stress from different factors, can lead to an overstimulation of the HPA axis, eventually causing its dysregulation
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