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The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig
Known as the "master antioxidant," glutathione is essential for protecting cells from oxidative stress and damage caused by free radicals
In the diabetic state, an increase in O-GlcNAc impairs endothelial cell migration and tube formation by reducing the activity and phosphorylation of Akt at serine 473 [54]
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