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1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells and regulates blood sugar by increasing insulin while reducing glucagon secretion and inhibiting stomach emptying and food intake ( Ocular diseases, including glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), impose a staggering global burden, with glaucoma alone affecting 95 million individuals and causing irreversible vision loss in over 10 million ( Emerging evidence positions GLP-1RAs as a transformative candidate for ocular therapeutics
The FDA has warned consumers about unapproved GLP-1 related drugs, including products containing semaglutide, tirzepatide, or retatrutide that may be sold illegally or labeled for research purposes while being promoted for human use
No lethal dose The LD50 of DSIP has never been determined because it has never been possible to kill an animal regardless of the dose administered
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