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Secondary endpoints included the proportion of participants achieving 5% and 10% body weight reduction, absolute weight change in kg, change in waist circumference, lipid parameters including total cholesterol, HDL, LDL, VLDL, triglycerides, and glycaemic variables such as HbA1c, fasting glucose, insulin, HOMA-IR, and -cell function

Petersburg looked at the effects of epitalon on body weight, food consumption, and lifespan in female Swiss SHR mice

Interestingly, TRIM37 mutants identified in MUL patients also lead to infertility in mouse models ( FIN major and G322V)

The surgery was performed on the right hind limb and the left limb served as a control