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GLP-1RAs inhibit RGC apoptosis in glaucoma through GABAergic signaling, but their role in AMD, characterized by oxidative stress and choroidal neovascularization, needs further investigation ( The latest diabetic retinopathy preferred practice guidelines from the American Academy of Ophthalmology indicate that the rising use of GLP-1RAs may lead to quick glycemic control and severe hypoglycemia and has been reported to cause higher rates of retinopathy complications, especially in patients with early-stage DR ( 4.2 Delivery optimization Systemic administration of GLP-1RAs reduces their availability in the retina and can lead to off-target effects, particularly gastrointestinal issues

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7), including members of the tumor necrosis factor superfamily (e.g., Tnf , Tnfrsf1b ), chemokines and their receptors (e.g., Ccl2 , Ccl3 , Ccr3 ), Toll-like receptors (e.g., Tlr1 , Tlr4 , Tlr8 , Tlr13 )

People who have a history of pancreatitis should discuss the risks with their doctor before starting the drugs