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In general, the most common cause of elevated homocysteine levels (hyperhomocysteinemia) is reduced activity of MTHFR, which causes low folate
This absence may result in upregulation of HBV core antigen expression, intensifying the host's immune response or altering the antigenic characteristics of HBV, thereby causing significant immunological damage
Gastroenterology 128, A584
If there is insufficient (or no) B12 in bloodstream, or it is not linking well with B12 at this stage, your MMA will increase in your bloodstream, and carry on increasing until B12 makes the journey and the required links
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