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Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
This is the first time the GIP/GLP-1 advantage over GLP-1 alone has been proven in a direct comparison, and it is why I treat "tirzepatide beats semaglutide" as a settled question rather than an open debate
The per member per month (PMPM) Rx spend for a diabetic member on GLP-1s was over 2.5x the Rx spend for a diabetic member not on GLP-1s
Modulating this system affects how the brain processes rewards, potentially explaining why users often report reduced cravings for highly palatable foods and, interestingly, decreased interest in addictive substances
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