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a 2025 review concluded that GLP-1R agonists reduce alcohol intake, lower the motivation to drink, and prevent relapse drinking in preclinical models [16]

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108 Overall, these studies suggest that although weight loss from dietary restriction can compromise skeletal health, incorporating exerciseparticularly endurance trainingcan preserve BMD and hormonal factors, and reduce bone resorption, thereby offering partial protection to the skeleton during obesity treatment

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