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In addition, reactions (rash or itching) at the injection site, insomnia, dizziness, and fatigue may occur
The SURMOUNT-4 trial showed that patients switched to placebo after initial weight loss regained about two-thirds of the weight they had lost within 36 weeks of stopping
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A 2024 review surveyed neurotransmitter-system interactions in this body of work (PMID 38675421), suggesting the compound's effects on central nervous system tissue may share mechanisms with its peripheral activity
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