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The extra CBS enzyme causes homocysteine to be lost through the transsulfuration pathway.[ref] What about low homocysteine

Scheffold A, Jebaraj BMC, Tausch E, Bloehdorn J, Ghia P, Yahiaoui A, et al

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Moreover, to achieve temperature-responsive transcriptional regulation of heterologous expression, two thermoregulated systems were engineered: (1) the phage-derived cI857/PL system employing a thermosensitive repressor, and (2) a synthetic P IbpA variant incorporating Pseudomonas aeruginosa IbpA-5UTR modifications