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Importantly, FOXO4-DRI showed no significant toxicity or impact on viability and apoptosis in normal TM3 Leydig cells, where FOXO4 expression is typically low
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Considering the potential for therapeutic development of (in)GSH, the established safety and tolerability data, biological plausibility, and pilot level clinical evidence of benefit are further supported with this demonstration that (in)GSH is able to augment brain GSH levels
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