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doi: 10.1177/0361684315581841 33 DuplagaM

Genetics of human malignant peripheral nerve sheath tumors

When comparing differentially expressed genes (DEGs) among healthy and disease-associated OL populations, PD-specific changes included a reduction in multiple genes involved in myelination (i.e., MBP, MOBP, MOG), glial-neuron adhesion (i.e., CTNNA3, NRXN3), as well as an increase in stress-response genes (i.e., HSP90AA1, FKBP5) and well-known neurodegenerative markers, such as MAPT which contains multiple PD-associated single nucleotide polymorphisms (SNPs) (Adams et al., 2024)

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