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The effects of DSIP on pain threshold during light and dark periods in rats are not naloxone-sensitive
In placebo-controlled adjunctive epilepsy trials in adults receiving topiramate 200 to 1,000 mg/day, hot flashes (1% to 2%), drug-induced body odor (0% to 1%), skin disorder (1% to 2%), hyperhidrosis (1% or less), and erythematous rash (1% or less) were reported with equal or greater frequency than placebo
These changes increase tyrosinase activity, promote eumelanin biosynthesis in melanosomes, and enhance melanosome maturation and transfer to keratinocytes, yielding photoprotective pigmentation
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