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While the PIONEER CVOT for oral semaglutide did not achieve statistical significance for MACE reduction [19] [48], the subcutaneous formulation demonstrated a clear benefit in the SUSTAIN-6 trial [15], a finding consistent with the broader class effect of GLP-1RAs [49, 50]
It works by mimicking the GLP-1 hormone in your body, which plays a key role in controlling hunger and influencing fat storage
Risk Factors include age (it usually affects people over 50), diabetes, hypertension, high cholesterol, sleep apnea, and anatomical predispositions such as a small cup-to-disc ratio
The financial picture for these medications reveals significant disparities in both brand-name pricing and availability of compounded alternatives
